שאלה משלב א׳ בא.א.ג וכירורגיה של ראש וצוואר · מועד 2020, שאלה 124

HPV-associated oropharyngeal carcinoma carries a significantly BETTER prognosis - which is why it is staged separately and why de-escalation protocols are under study. It typically occurs in YOUNGER patients (40s-50s) who are non-smokers and non-drinkers, with a history of multiple sexual partners, and its histology is NON-keratinising with basaloid features; p16 immunohistochemistry (with HPV testing) is the diagnostic marker.

מקור: ראש צוואר1432