שאלה משלב א׳ במחלות עור ומין · מועד 2025, שאלה 133

PAGETOID RETICULOSIS (Woringer-Kolopp) and HYPOPIGMENTED MYCOSIS FUNGOIDES share the possibility of a CYTOTOXIC CD3+ CD8+ CD4- PHENOTYPE of the malignant cells, which in hypopigmented disease accounts for the melanocyte damage and loss of pigment. Both are LOCALISED (pagetoid reticulosis being a solitary acral plaque) rather than widespread, both are INDOLENT with excellent survival, and in both the infiltrate is EPIDERMOTROPIC (markedly intraepidermal) rather than dermal.

מקור: Bolognia p. 2165