שאלה משלב א׳ בהרדמה · מועד 2021, שאלה 42

Warfarin inhibits vitamin K-dependent carboxylation of factors II, VII, IX and X and of proteins C and S. Protein C has the shortest half-life (about 6–8 hours, with factor VII), so it is the first to fall. This creates an early transient hypercoagulable state (warfarin skin necrosis), which is why bridging with heparin or enoxaparin continues until the INR is therapeutic. Resuming warfarin early after the procedure shortens the time on bridging.

מקור: Miller p. p.427