שאלה משלב א׳ בכירורגיה אורולוגית · מועד 2025, שאלה 80

Correct: B — finasteride reduced the overall incidence of prostate cancer by 25%. That was the principal finding of the Prostate Cancer Prevention Trial, accompanied by an apparent excess of Gleason 7 and above tumours in the finasteride arm — later attributed largely to the detection effects of a smaller gland and lower PSA — so option A inverts that finding and option D's claim of a reduction in high-grade tumours is wrong. Option C denies the trial's central result. Long-term follow-up showed no difference in overall or cancer-specific mortality, which is why finasteride was never approved for chemoprevention.

מקור: Campbell-Walsh p. 3473