שאלה משלב א׳ בפתולוגיה אבחנתית · מועד 2021, שאלה 110

APOL1 risk alleles (G1 and G2, carried by people of West African ancestry and protective against trypanosomiasis) markedly increase the risk of FOCAL SEGMENTAL GLOMERULOSCLEROSIS, as well as HIV-associated nephropathy and hypertensive kidney disease progressing to end-stage renal failure. Alport syndrome (COL4A5), membranous nephropathy (PLA2R) and IgA nephropathy have different genetics.

מקור: Robbins p. 20 916