שאלה משלב א׳ בנוירוכירורגיה · מועד 2020, שאלה 136

Correct: B — the statement that is NOT true is that the gene lies on the short arm of chromosome 13; the VHL gene is on the short arm of chromosome 3 (3p25-26). Option A is true in that loss of pVHL function leads to activation of downstream oncogenic signalling including C-myc; option C is true because pulmonary and renal, pancreatic and epididymal cysts are part of the syndrome; option D is true because pVHL targets HIF-1alpha for degradation.

מקור: ב,דYoumans, Vol 2, page 1215