שאלה משלב א׳ במיקרוביולוגיה קלינית · מועד 2022, שאלה 79

Correct: B — the production of a protease of altered structure. Boceprevir is an NS3/4A protease inhibitor, and resistance arises through amino-acid substitutions in that protease. Option A, enzymatic degradation of the drug, does not occur; option C misplaces the mutations, which are in the enzyme itself rather than in drug binding sites elsewhere; option D is wrong because resistance-associated substitutions were described early.