שאלה משלב א׳ בא.א.ג וכירורגיה של ראש וצוואר · מועד 2026, שאלה 34

מפתח התשובות של שאלה זו עודכן לאחר העררים.

Answers א, ב and ג were all accepted. IL-5 is the principal eosinophil cytokine - driving their differentiation, recruitment, activation and survival - while IL-4 and IL-13 promote eosinophil trafficking into the tissue by inducing VCAM-1 on the endothelium and eotaxin (CCL11, CCL24) production, so all three contribute to eosinophil migration into the nasal mucosa. This is the basis of mepolizumab/reslizumab (anti-IL-5) and dupilumab (anti-IL-4R-alpha) therapy; IL-33 is an upstream epithelial alarmin acting through ILC2 and TH2 cells.